Xya xyoo rov qab, cov niam txiv ntawm Yuto Amakawa tuag nyob rau hauv lub tsheb sib tsoo, cia nws nyob ib leeg yam tsis muaj ib yam dab tsi sab laug ntawm nws tsev neeg, ib tug txheeb ze yog ib tug mysterious thiab peculiar amulet muab rau nws los ntawm nws pog yawg. Txij thaum ntawd los, nws tus phooj ywg thaum yau Rinko Kuzaki (thiab nws niam nws txiv [ch. 1]) tau ua noj rau thiab saib xyuas nws. Thaum nws ntsib ib tug miv dab samurai poj niam, Himari nws lub neej yuav siv sij hawm ib tug radical tig. Himari qhia rau nws tias ntau tus ntawm nws cov poj koob yawm txwv yog ib feem ntawm kaum ob Demon Slayer tsev neeg uas tau tua dab vim muaj hnub nyoog feudal. Nws tau cog lus cog lus los tiv thaiv Yuto los ntawm dab ntxwg nyoog uas tawm los rhuav tshem nws, tab sis kev tsis haum rau cov miv ntawm Yuto ua rau nws nyuaj rau kev saib xyuas.
Tom qab ntawd, Yuto ntog rau ntau tus poj niam uas nyiam nws: Shizuku, mizuchi los ntawm ib tug me nyuam me; Lizlet, ib tug tsukumogami los ntawm txoj kev ntawm ib tug busty tshuaj yej pab tub txib; thiab Kuesu, tseem yog lwm tus Dab Slayer uas tau qhia tias yog Yuto tus fiancee nrog rau ib tug txiv neej los ntawm Yuto txoj kev ploj lawm yav dhau los.
Raws li kev ua yeeb yam tau nce mus, pawg thiab Yuto poob rau qee qhov muaj zog ayakashi, nrog qee tus ntawm lawv yog cov phooj ywg, thiab Yuto thaum kawg ua rau kev hloov pauv lub neej los tawm tsam vim nws txoj kev xav ntawm kev sib koom ua ke ntawm ayakashi thiab tus kheej.
